Apamin (TFA)

• Description :

  Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity[1].

• Product Name Alternative :

  Apamine (TFA)

• UNSPSC :

  12352209

• Target :

  Potassium Channel

• Type :

  Peptides

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/apamin-tfa.html

• Purity :

  97.03

• Solubility :

  H2O : 50 mg/mL (ultrasonic)

• Smiles :

  O=C1[C@@]2([H])N(C([C@@H](NC([C@@H](NC([C@@]3([H])NC([C@@H](NC([C@H](CSSC[C@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC3)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N)=O)CC4=CN=CN4)=O)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C)=O)([H])NC([C@@H](NC([C@@H](NC([C@](NC([C@@H](N1)CCC(O)=O)=O)([H])[C@H](O)C)=O)C)=O)CC(C)C)=O)N)=O)CC(N)=O)=O)=O)CCCCN)=O)C)=O)CCC2.O=C(O)C(F)(F)F

• Molecular Formula :

  C81H132F3N31O26S4

• Molecular Weight :

  2141.36

• References & Citations :

  [1]Kim JY, et al. Apamin suppresses biliary fibrosis and activation of hepatic stellate cells. Int J Mol Med. 2017 May;39 (5) :1188-1194.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported