Apamin

• Description:

  Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity[1].

• Product Name Alternative:

  Apamine

• UNSPSC:

  12352209

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Potassium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Apamin.html

• Purity:

  99.96

• Solubility:

  H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=C([C@@H](N)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N[C@H]2CCCNC(N)=N)=O)CCCNC(N)=N)=O)C)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CC(C)C)=O)C)=O)[C@@H](C)O)=O)CCC(O)=O)=O)CCC3)=O)C)=O)CCCCN)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC4=CNC=N4)=O)CCC(N)=O)=O)CCC(N)=O)=O)=O)CC(N)=O

• Molecular Formula:

  C79H131N31O24S4

• Molecular Weight:

  2027.34

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Kim JY, et al. Apamin suppresses biliary fibrosis and activation of hepatic stellate cells. Int J Mol Med. 2017 May;39 (5) :1188-1194.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [24345-16-2]