BP-1-102

CAT: 0804-HY-100493-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100493-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC50 of 6.8 μM.
CAS Number
[1334493-07-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335, H412
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BP-1-102.html
Concentration
10mM
Purity
99.52
Solubility
DMSO : ≥ 33 mg/mL
Smiles
O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O)C=C1O
Molecular Formula
C29H27F5N2O6S
Molecular Weight
626.59
Precautions
H302, H315, H319, H335, H412
References & Citations
[1]Zhang X, et al. Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. Proc Natl Acad Sci U S A. 2012 Jun 12;109 (24) :9623-8.|[2]De Simone V, et al. Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene. 2015 Jul;34 (27) :3493-503.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3

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Alternative Products

CatalogName
MBS3601334-01BP-1-102
443383BP 1-102
A20347-50BP-1-102 50mg
A20347-100BP-1-102 100mg
A20347-1BP-1-102 1mg
A20347-2BP-1-102 2mg
A20347-5BP-1-102 5mg
A20347-10BP-1-102 10mg
A20347-25BP-1-102 25mg
A20347-10mM-DBP-1-102 10mM * 1mL in DMSO

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