PPQ-102

• Description :

  PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM) . PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease[1].

• Product Name Alternative :

  CFTR Inhibitor

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H317

• Target :

  CFTR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/PPQ-102.html

• Purity :

  99.73

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  CN1C(C2=C(C3=CC=CC=C3)N4C5=CC=CC=C5NC(C6=CC=C(C)O6)C4=C2N(C)C1=O)=O

• Molecular Formula :

  C26H22N4O3

• Molecular Weight :

  438.48

• Precautions :

  H302, H317

• References & Citations :

  [1]Tradtrantip L, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52 (20) :6447-55.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [931706-15-9]