PPQ-102

• UNSPSC Description:

  PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease[1].

• Target Antigen:

  CFTR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/PPQ-102.html

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CN1C(C2=C(C3=CC=CC=C3)N4C5=CC=CC=C5NC(C6=CC=C(C)O6)C4=C2N(C)C1=O)=O

• Molecular Weight:

  438.48

• References & Citations:

  [1]Tradtrantip L, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52(20):6447-55.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  931706-15-9