BGB-102

• Description :

  BGB-102 is a potent multi-kinase inhibitor against EGFR, HER2, and HER4 with IC50s of 9.6 nM, 18 nM and 40.3 nM, respectively.

• Product Name Alternative :

  JNJ-26483327

• UNSPSC :

  12352005

• Target :

  EGFR

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/BGB-102.html

• Purity :

  99.52

• Solubility :

  DMSO : 4.4 mg/mL (ultrasonic) |THF : ≥ 7.27 mg/mL

• Smiles :

  CN1CCCCCOC(C(OC)=C2)=CC3=C2N=CN/C3=N\C4=CC(Br)=CC=C4C1

• Molecular Formula :

  C22H25BrN4O2

• Molecular Weight :

  457.36

• References & Citations :

  [1]Gijsen M, et al. HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biol. 2010 Dec 21;8 (12) :e1000563.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  EGFR/ErbB1/HER1; ErbB2/HER2; ErbB4/HER4

• CAS Number :

  [807640-87-5]