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CIL-102

CAT: 0804-HY-133845Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-133845Size:1 Each
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Description
CIL-102, an apoptosis inducer, is a MMP-2/MMP-9 inhibitor that decreases MMP-2/MMP-9 protein expression and mRNA levels. CIL-102 displays an anti-cancer activity[1].
CAS Number
479077-76-4
UNSPSC
12352005
Target
Apoptosis; MMP
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CC(C1=CC=C(NC2=C3C(OC=C3)=NC4=CC=CC=C24)C=C1)=O
Molecular Formula
C19H14N2O2
Molecular Weight
302.33
References & Citations
[1]Liu WH, et al. CIL-102 induces matrix metalloproteinase-2 (MMP-2) /MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability. Int J Biochem Cell Biol. 2012 Dec;44 (12) :2212-22.|[2]Huang WS, et al. CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45. PLoS One. 2017 Jan 9;12 (1) :e0168989.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-2; MMP-9

Chemical Information

1-(4-(Furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone

anti-tumor agent; structure in first source

CAS Number479077-76-4
PubChem CID404353
IUPAC Name1-[4-(furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone
Molecular FormulaC19H14N2O2
Molecular Weight302.3
XLogP3.9
Topological Polar Surface Area55.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity433
SMILES
CC(=O)C1=CC=C(C=C1)NC2=C3C=COC3=NC4=CC=CC=C42
InChI
InChI=1S/C19H14N2O2/c1-12(22)13-6-8-14(9-7-13)20-18-15-4-2-3-5-17(15)21-19-16(18)10-11-23-19/h2-11H,1H3,(H,20,21)
InChIKey
VJDPGTFIMDGXDQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(4-(Furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone
CAS: 479077-76-4
CID: 404353
Formula: C19H14N2O2
MW: 302.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight302.3
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass302.105527694
Monoisotopic Mass302.105527694
Topological Polar Surface Area55.1 Ų
Heavy Atom Count23
Formal Charge0
Complexity433
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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