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RG-7152

CAT: 0804-HY-19109-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19109-01Size:1 mg
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Description
RG-7152 is a tetrazolyl-substituted leukotriene D4 receptor antagonist that can induce peroxisomal β-oxidation and peroxisome bifunctional enzymes (PBEs) in hepatocytes in various animal models. It has been shown to significantly increase PBE levels and β-oxidation activity in rat and mouse liver homogenates, while smaller effects were observed in guinea pigs and monkeys and no effect in dogs. In vitro studies have also shown that it can induce PBEs comparable to clofibric acid, indicating its potential as a peroxisome proliferator[1].
CAS Number
107813-63-8
UNSPSC
12352005
Target
Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/rg-7152.html
Smiles
C1(COC2=CC=CC(OCCCC3=NN=NN3)=C2)=NC4=CC=CC=C4C=C1
Molecular Formula
C20H19N5O2
Molecular Weight
361.40
References & Citations
[1]Kelley M, et al. Induction of peroxisomal enzymes by a tetrazole-substituted 2-quinolinylmethoxy leukotriene D4 antagonist. Fundam Appl Toxicol. 1994 Aug;23 (2) :298-303.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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