RegisterLogin

RG-15

CAT: 0804-HY-171328-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-171328-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
RG-15 is the orally active antagonist for dopamine receptor that exhibits goof affinity to human D2 receptor and human D3 receptor with pKi of 8.23 and 10.49. RG-15 inhibits dopamine-stimulated [35S]GTPγS binding with IC50 of 21.2 nM (rat striatal membranes), 36.7 nM (mouse A9 cells expressing human D2L receptors) and 7.2 nM (CHO cells expressing human D3 receptors) . RG-15 increases the turnover and biosynthesis of dopamine in mouse striatum and olfactory bulb, exhibiting antipsychotic activity[1].
CAS Number
[1076189-55-3]
UNSPSC
12352005
Target
Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Purity
95.18
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC(F)(C1=CC(C#N)=CC(N2CCN(CC2)CC[C@H]3CC[C@@H](CC3)NS(=O)(C4=CN=CC=C4)=O)=C1)F.Cl.Cl
Molecular Formula
C25H32Cl2F3N5O2S
Molecular Weight
594.52
References & Citations
[1]Kiss B, et al., Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15. Naunyn Schmiedebergs Arch Pharmacol. 2008 Nov;378 (5) :515-28.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-164248-01Ac-rG
HY-116138RG-14467
HY-19190RG-201
HY-P990658-01RG-7652
HY-132600RG-101
HY-43057-01IBu-rG
HY-120238RG 13647
HY-19109-01RG-7152
HY-P991467RG-7258
HY-114636RG-102240

Alternative Products

CatalogName
T206486-01RG-15
26-6765G-15N3-rG 15 umol scale
27-6434-158-Oxo rG [8-Oxo-rG] 15 umol scale
27-6765G-15Azide rG 15 umol scale
27-6943-15L-RNA rG 15 umol scale
27-6400G-15RG RNA Base 15 umol scale
27-6446-158-Br rG 15 umol scale
27-6443-15Inverted rG (reverse linkage) 15 umol scale
27-6533-15Thio 6-rG (s6rG) 15 umol scale
RM-G400015-01Glucose Impurity 15 discontinued see RG-A080301

Popular Products