C3N-Dbn-Trp2

CAT: 0804-HY-162714Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-162714Size:1 Each

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Description

C3N-Dbn-Trp2 is an inhibitor for ATP-binding cassette transporter ABCB1. C3N-Dbn-Trp2 inhibits the ABCB1-mediated Rhodamine 123 efflux in cells HEK293T and HCT-15 with IC50 of 5.9 µM and 2.2 µM. C3N-Dbn-Trp2 inhibits the Doxorubicin (HY-15142A) efflux, enhances the cytotoxicity of Doxorubicin in ABCB1-expressing cells[1].

CAS Number

2631659-57-7

UNSPSC

12352005

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/c3n-dbn-trp2.html

Smiles

[H][C@@]12N(CC3=CC=CC=C3)C4=CC=CC=C4[C@]1(CC5=CC=CC=C5)C[C@]6([H])N2C([C@@](CC7=CNC8=C7C=CC=C8)([H])NC6=O)=O

Molecular Formula

C36H32N4O2

Molecular Weight

552.66

References & Citations

[1]Koh JYP, et al., Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors. Commun Chem. 2024 Jul 13;7 (1) :158.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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