C3N-Dbn-Trp2

CAT: 0931-T88512-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T88512-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2631659-57-7

Target

P-gp

Related Pathways

Neuroscience, Membrane transporter/Ion channel

Bioactivity

C3N-Dbn-Trp2 is an inhibitor of the ATP-binding cassette transporter ABCB1. It inhibits the efflux of Rhodamine 123 mediated by ABCB1 in HEK293T and HCT-15 cells, with IC50 values of 5.9 μM and 2.2 μM, respectively. Additionally, C3N-Dbn-Trp2 inhibits the efflux of Doxorubicin, thereby enhancing the cytotoxicity of Doxorubicin in cells expressing ABCB1.

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C([C@]12[C@](N3[C@@](C1)(C(=O)N[C@@H](CC=4C=5C(NC4)=CC=CC5)C3=O)[H])(N(CC6=CC=CC=C6)C=7C2=CC=CC7)[H])C8=CC=CC=C8

Molecular Formula

C36H32N4O2

Molecular Weight

552.66

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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