TRPM2-IN-2

• Description:

  TRPM2-IN-2 is a potent and selective TRPM2 inhibitor (IC50 = 0.66 μM) with minimal activity against TRPM8 and TRPV1 (IC50 >10 μM) . TRPM2-IN-2 exhibits robust neuroprotective effects in both in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model and in vivo transient middle cerebral artery occlusion (tMCAO) mouse model. TRPM2-IN-2 can be used for ischemic stroke research[1].

• UNSPSC:

  12352005

• Target:

  TRP Channel

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Neurological Disease; Metabolic Disease

• Smiles:

  O=C(N1CCCC1)C2=CC3=CC=CN3C(C(NC4(C[C@H]5C6)C[C@H]6C[C@H](C5)C4)=O)=C2

• Molecular Formula:

  C24H29N3O2

• Molecular Weight:

  391.51

• References & Citations:

  [1]Lu T, et al. Discovery of adamantyl derivatives as potent and selective TRPM2 inhibitors with significantly reduced hERG liability. Eur J Med Chem. 2025 Dec 15;300:118172.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TRPM2