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RIP1/RIP3/MLKL activator 1

CAT: 0804-HY-144828-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144828-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RIP1/RIP3/MLKL activator 1 (Compound 6i) is a potent anti-glioma agent. RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway. RIP1/RIP3/MLKL activator 1 exerts acceptable BBB permeability[1].
CAS Number
2682850-41-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Mixed Lineage Kinase; Necroptosis; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rip1-rip3-mlkl-activator-1.html
Purity
97.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C(C=C2C1=CC=C3[C@]4(CC[C@]5(CC[C@@](C(NCC6=CN(N=N6)CC7=CC=C(C=C7)C(C)(C)C)=O)(CC5[C@@]4(CC[C@@]23C)C)C)C)C)=O)O
Molecular Formula
C43H56N4O3
Molecular Weight
676.93
Precautions
H302, H315, H319, H335
References & Citations
[1]Yao Feng, et al. Synthesis and biological evaluation of celastrol derivatives as potential anti-glioma agents by activating RIP1/RIP3/MLKL pathway to induce necroptosis. Eur J Med Chem. 2022 Feb 5;229:114070.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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