ZBP1/RIP3/MLKL activator 1
CAT:
804-HY-162424
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
ZBP1/RIP3/MLKL activator 1
- UNSPSC Description: ZBP1/RIP3/MLKL activator 1 (compound 3a) is a synthetically derived quinoline compound. ZBP1/RIP3/MLKL Activator 1 induces DNA damage, enhances intracellular levels of reactive oxygen species (ROS), and triggers apoptosis via the caspase pathway. Furthermore, when apoptosis is inhibited, ZBP1/RIP3/MLKL Activator 1 promotes necroptotic cell death through the ZBP1-RIP3-MLKL pathway. ZBP1/RIP3/MLKL Activator 1 is utilized in oncological research, particularly in the selective targeting of cells with impaired apoptotic function[1].
- Target Antigen: Mixed Lineage Kinase; Necroptosis; RIP kinase
- Type: Reference compound
- Related Pathways: Apoptosis;MAPK/ERK Pathway
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/zbp1-rip3-mlkl-activator-1.html
- Smiles: CN(C)CCCNC1=NC2=CC([N+]([O-])=O)=CC=C2N=C1NCC3=CC=C(C4=CC=CC=C4)C=C3
- Molecular Weight: 456.54
- References & Citations: [1]Saha R, et al. Mono-quinoxaline-induced DNA structural alteration leads to ZBP1/RIP3/MLKL-driven necroptosis in cancer cells[J]. European Journal of Medicinal Chemistry, 2024, 270: 116377.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported