RIP1-IN-1

• Target:

  Necroptosis|||RIP kinase

• Related Pathways:

  NF-?B|||Apoptosis

• Bioactivity:

  RIP1-IN-1 is an orally bioavailable RIP1 inhibitor with a high binding affinity (Kd: 110 nM) . This compound exhibits significant activity against necroptosis and effectively suppresses necrosome formation by inhibiting the phosphorylation of RIP1, RIP3, and MLKL pathways. RIP1-IN-1 can inhibit necroptosis and is applicable in research on acute liver injury.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C