RIP3 activator 1

CAT: 0804-HY-168640Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-168640Size:1 Each
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Description
RIP3 activator 1 (compound C8) is a potent RIP3 activator. RIP3 activator 1 inhibits cell growth. RIP3 activator 1 induces necroptosis through the RIP3/p62/Keap1 signaling pathway. RIP3 activator 1 increases the protein expression of p-MLKL. RIP3 activator 1 induces autophagy. RIP3 activator 1 increases accumulation of LC3-II and p62 protein expression[1].
CAS Number
[1456899-52-7]
UNSPSC
12352211
Target
Autophagy; Necroptosis; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rip3-activator-1.html
Smiles
O[C@@H]1[C@@H](N)CO[C@H]1COCC(N=N2)=CN2CCCCCCCCCCCCCCCCCC
Molecular Formula
C26H50N4O3
Molecular Weight
466.70
References & Citations
[1]Liu X, et al. The RIP3 activator C8 regulates the autophagy flux mediated by p62 and promotes the immunogenic form of cell death in human gastric cancer cells. Bioorg Chem. 2024 Nov 3;153:107937.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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