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Ebselen oxide

CAT: 0804-HY-114548-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114548-01Size:1 mg
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Description
Ebselen oxide, the selenone analogue of Ebselen, covalently modifies diguanylate cyclase (DGC) to inhibit c-di-GMP-receptor interactions and reduces DGC activity. Ebselen oxide also inhibits alginate production (IC50=14 μM) by Pseudomonas aeruginosa. Ebselen oxide inhibits HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9 (IC50 ranging from 0.2 to 4.7 μM) [1][2][3].
CAS Number
104473-83-8
UNSPSC
12352005
Hazard Statement
H301+H331-H315-H335-H373-H410
Target
Guanylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ebselen-oxide.html
Purity
98.0
Solubility
DMSO : 5 mg/mL (ultrasonic; warming)
Smiles
O=[Se]1N(C(C2=C1C=CC=C2)=O)C3=CC=CC=C3
Molecular Formula
C13H9NO2Se
Molecular Weight
290.18
Precautions
P260-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P391-P403+P233-P405-P501
References & Citations
[1]Lieberman OJ, et al. High-throughput screening using the differential radial capillary action of ligand assay identifies ebselen as an inhibitor of diguanylate cyclases. ACS Chem Biol. 2014;9 (1) :183-192. |[2]Kim SK, et al. Inhibition of Pseudomonas aeruginosa Alginate Synthesis by Ebselen Oxide and Its Analogues. ACS Infect Dis. 2021;7 (6) :1713-1726. |[3]Wang Y, et al. Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs. Drug Des Devel Ther. 2017;11:1369-1382. Published 2017 May 2.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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