Ebselen

• UNSPSC Description:

  Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker[1][2]. Ebselen potently inhibits Mpro (IC50=0.67 μM) and COVID-19 virus (EC50=4.67 μM)[3].Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity[4][5].

• Target Antigen:

  Calcium Channel; HIV; Phosphatase; Virus Protease

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling

• Field of Research:

  Cancer; Infection; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Ebselen.html

• Smiles:

  O=C1N(C2=CC=CC=C2)[Se]C3=C1C=CC=C3

• Molecular Weight:

  274.181

• References & Citations:

  [1]Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208.|[2]Singh N, et al. A safe lithium mimetic for bipolar disorder. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320.|[3]Hanavan PD, et al. Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines. Oncotarget. 2015 Jul 30;6(21):18418-28.|[4]Liang Q, et al. Electrical Stimulation Degenerated Cochlear Synapses Through Oxidative Stress in NeonatalCochlear Explants. Front Neurosci. 2019 Oct 14;13:1073.|[5]H Sies, et al. Ebselen, a Selenoorganic Compound as Glutathione Peroxidase Mimic|[6]Jin Z, et al. Structure of M^pro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  60940-34-3