Ebselen

• Description:

  Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker[1][2]. Ebselen potently inhibits Mpro (IC50=0.67 μM) and COVID-19 virus (EC50=4.67 μM) [3].Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity[4][5].

• Product Name Alternative:

  SPI-1005; PZ-51; CCG-39161

• UNSPSC:

  12352005

• Hazard Statement:

  H301+H331, H373, H410

• Target:

  Calcium Channel; HIV; Phosphatase; Virus Protease

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Ebselen.html

• Purity:

  99.91

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1N(C2=CC=CC=C2)[Se]C3=C1C=CC=C3

• Molecular Formula:

  C13H9NOSe

• Molecular Weight:

  274.18

• Precautions:

  H301+H331, H373, H410

• References & Citations:

  Pro

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  HIV-1

• CAS Number:

  [60940-34-3]