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Phenylarsine oxide

CAT: 0804-HY-131901-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131901-01Size:100 mg
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Description
Phenylarsine oxide (PAO), an inhibitor of endocytosis, inhibits PTPε with an IC50 of 18 μM. Phenylarsine oxide (PAO) inhibits oxygen consumption and decreases cellular ATP content overlap with those used to inhibit protein internalization[1][2].
CAS Number
637-03-6
Product Name Alternative
Oxophenylarsine; PhAsO; Arsenosobenzene
UNSPSC
12352005
Hazard Statement
H301+H331, H410
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/phenylarsine-oxide.html
Purity
99.32
Solubility
DMSO : 40 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=[As]C1=CC=CC=C1
Molecular Formula
C6H5AsO
Molecular Weight
168.02
Precautions
H301+H331, H410
References & Citations
[1]A Schmidt, et al. Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate. Proc Natl Acad Sci U S A. 1996 Apr 2;93 (7) :3068-73.|[2]A E Gibson, et al. Phenylarsine oxide inhibition of endocytosis: effects on asialofetuin internalization. Am J Physiol. 1989 Aug;257 (2 Pt 1) :C182-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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