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Ebselen derivative 1

CAT: 0804-HY-163506Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163506Size:1 Each
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Description
Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin -induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394) -induced hearing loss.
CAS Number
3030492-59-9
UNSPSC
12352005
Target
Apoptosis; Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ebselen-derivative-1.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C([Se]N1C3=CC=CN=C3)C(OC)=CC=C2
Molecular Formula
C13H10N2O2Se
Molecular Weight
305.19
References & Citations
[1]Wang W, et al. Quantum chemistry calculation-aided discovery of potent small-molecule mimics of glutathione peroxidases for the treatment of cisplatin-induced hearing loss. Eur J Med Chem. 2024;271:116404.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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