Ebselen derivative 1

• UNSPSC Description:

  Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394)-induced hearing loss [1].

• Target Antigen:

  Apoptosis; Ferroptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/ebselen-derivative-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=C([Se]N1C3=CC=CN=C3)C(OC)=CC=C2

• Molecular Weight:

  305.19

• References & Citations:

  [1]Wang W, et al. Quantum chemistry calculation-aided discovery of potent small-molecule mimics of glutathione peroxidases for the treatment of cisplatin-induced hearing loss. Eur J Med Chem. 2024;271:116404.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3030492-59-9