PPARγ agonist 15

CAT: 0804-HY-169404Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-169404Size:1 Each

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Description

PPARγ agonist 15 (Compound 7c) is an agonist for PPARγ. PPARγ agonist 15 inhibits the expression of alpha-amylase (HPA) and alpha-glucosidase (HLAG) with IC50 of 28.35 µM and 26.21 µM. PPARγ agonist 15 enhances glucose uptake in the L6 myotube cell. PPARγ agonist 15 improves glucose homeostasis, insulin sensitivity, and lipid metabolism in rat Streptozotocin -induced diabetes model[1].

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pparγ-agonist-15.html

Smiles

COC1=CC=C(C2=CSC(N/N=C\C3=CC=C(/C=C4SC(NC\4=O)=O)C=C3)=N2)C=C1

Molecular Formula

C21H16N4O3S2

Molecular Weight

436.51

References & Citations

[1]Gharge S, et al. Expression of PPAR-γ TF by newly synthesized thiazolidine-2,4-diones to manage glycemic control: Insights from in silico, in vitro and experimental pharmacology in wistar rats. Bioorg Chem. 2024 Dec;153:107966.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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PPARγ agonist 15

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