Products for Research Use Only
RegisterLogin

FAN1 rabbit pAb

CAT: 0855-ES16526-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES16526-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2016]
Description
This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2016],
UniProt
Q9Y2M0
Swiss Prot
Q9Y2M0
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human FAN1 AA range: 801-851
Target
FAN1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus . Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2 (PubMed:20603015, PubMed:20603016) . Localizes to stalled replication forks via its UBZ4-type zinc finger (PubMed:20935496) . .
Gene ID (Human)
22909

UniProtKB · Q9Y2M0

Fanconi-associated nuclease 1

FAN1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y2M0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FAN1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.21.-, 3.1.4.1
Processing
—
Secondary accessions
A8K4M2, Q86WU8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Domain

Coiled coilZinc-finger

Disease

Disease variant

Biological process

DNA damageDNA repair

Molecular function

EndonucleaseExonucleaseHydrolaseNuclease

Ligand

MagnesiumManganeseMetal-bindingZinc

Cellular component

Nucleus

PTM

PhosphoproteinUbl conjugation

Related Products

CatalogName
ES16527-01FAN rabbit pAb
ES4666-01RAB3IP rabbit pAb
ES20751-01Gab1 Rabbit rabbit pAb
ES20703-01JAK2 Rabbit rabbit pAb
ES20758-01ERK1 Rabbit rabbit pAb
ES20659-01NBR1 Rabbit rabbit pAb
ES20825-01ATG7 Rabbit rabbit pAb
ES20831-01ATG13 Rabbit rabbit pAb
ES20599-01VEGF Rabbit rabbit pAb
ES20596-01WIPI2 Rabbit rabbit pAb

Alternative Products

CatalogName
UB-GEN-12179FAN1 rabbit pAb
GTR17743529-01FAN1 Rabbit Polyclonal Antibody
GTR18403273-01FAN1 rabbit pAb Antibody
SL13137R-01Rabbit Anti-FAN1 antibody
GTR17747068FAN1 Rabbit Polyclonal Antibody (PE)
GTR17814766FAN1 Rabbit Polyclonal Antibody (APC)
GTR17734697FAN1 Rabbit Polyclonal Antibody (Biotin)
GTR17712528FAN1 Rabbit Polyclonal Antibody (HRP)
GTR18499902FAN1 Rabbit Polyclonal Antibody (PerCP)
WP17589-01U-Blot® FAN1 rabbit pAb

Popular Products