H2S probe 1

H2S probe 1

• UNSPSC Description: H2S probe 1 (compound 1NND) is a derivative of nitrobenzoxadiazole (NBD) with antitumor activity. H2S probe 1 is cytotoxic to human pancreatic cancer cell MIA PaCa-2 (IC50=77.9 nM) and has a high affinity for human telomeric G-quadruplex (G4) (Kd=1.72 μM). H2S probe 1 can be used in cancer research[1].
• Target Antigen: G-quadruplex
• Type: Dye Reagents
• Related Pathways: Cell Cycle/DNA Damage
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/h2s-probe-1.html
• Smiles: O=C(N(CCCN1CCOCC1)C2=O)C3=CC=C4C5=C(C(N(CCCN6CCOCC6)C4=O)=O)C=C(NCCN7CCN(C8=CC=C([N+]([O-])=O)C9=NON=C98)CC7)C2=C53
• Molecular Weight: 810.85
• References & Citations: [1]Xinhang Zhang, et al. "Design and synthesis of dual functional NBD-fluorophore-incorporated naphthalene diimide derivatives as G-quadruplex ligands." Bioorganic & Medicinal Chemistry Letters 111 (2024): 129903.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported