H2S probe 1

• Description :

  H2S probe 1 (compound 1NND) is a derivative of nitrobenzoxadiazole (NBD) with antitumor activity. H2S probe 1 is cytotoxic to human pancreatic cancer cell MIA PaCa-2 (IC50=77.9 nM) and has a high affinity for human telomeric G-quadruplex (G4) (Kd=1.72 μM) . H2S probe 1 can be used in cancer research[1].

• UNSPSC :

  12171500

• Target :

  G-quadruplex

• Type :

  Dye Reagents

• Related Pathways :

  Cell Cycle/DNA Damage

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/h2s-probe-1.html

• Smiles :

  O=C(N(CCCN1CCOCC1)C2=O)C3=CC=C4C5=C(C(N(CCCN6CCOCC6)C4=O)=O)C=C(NCCN7CCN(C8=CC=C([N+]([O-])=O)C9=NON=C98)CC7)C2=C53

• Molecular Formula :

  C40H46N10O9

• Molecular Weight :

  810.85

• References & Citations :

  [1]Xinhang Zhang, et al. "Design and synthesis of dual functional NBD-fluorophore-incorporated naphthalene diimide derivatives as G-quadruplex ligands." Bioorganic & Medicinal Chemistry Letters 111 (2024) : 129903.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Dye Reagents

• Clinical Information :

  No Development Reported