RegisterLogin

UNC8153 (TFA)

CAT: 0804-HY-157251-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-157251-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2) -targeted degrader with a Kd of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2[1].
CAS Number
[2929304-61-8]
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc8153-tfa.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C(F)(F)F)O.O=C(C1=CC=C(CN(C2CC2)C(C3=CC=C4NC(COC4=C3)=O)=O)C=C1)NC5=CC=C(C(NCCCCCCN)=O)C=C5
Molecular Formula
C35H38F3N5O7
Molecular Weight
697.70
References & Citations
[1]Ronan P Hanley, et al. Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. J Am Chem Soc. 2023 Apr 12;145 (14) :8176-8188.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-157251A-01UNC8153
HY-P3460A-01TDSRCVIGLYHPPLQVY (TFA)
HY-P5229A-01IHRIC (TFA)
HY-P1149A-01Epitalon (TFA)
HY-P0205B-01Saralasin (TFA)
HY-P3333A-01KSPWFTTL (TFA)
HY-P10582A-01SIYNFEKL (TFA)
HY-P1120AWKYMVm (TFA)
HY-D1690SBADA (TFA)
HY-P2093AS961 (TFA)

Alternative Products

CatalogName
BUP01467-01UNC8153 TFA
T88389-01UNC8153
A24332-1UNC8153 1mg
A24332-5UNC8153 5mg
A24332-10UNC8153 10mg
A24332-50UNC8153 50mg
MBS3611039-01Dermorphin TFA
M40534-01Katacalcin TFA
M40541-01Tirzepatide TFA
M40587-01Chlorotoxin TFA

Popular Products