UNC8153

CAT: 0931-T88389-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T88389-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2929304-60-7
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Bioactivity
UNC8153 is a selective degrader of the nuclear receptor binding SET domain-containing 2 (NSD2), with a binding Kd of 24 nM. It effectively reduces NSD2 protein levels and the dimethylation of lysine 36 on histone 3 (H3K36me2) chromatin. Its simple warhead promotes proteasome-dependent degradation of NSD2 through a novel mechanism.
Smiles
O=C(NC1=CC=C(C=C1)C(=O)NCCCCCCN)C2=CC=C(C=C2)CN(C(=O)C3=CC=C4NC(=O)COC4=C3)C5CC5
Molecular Formula
C33H37N5O5
Molecular Weight
583.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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CatalogName
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