EAAT2 activator 1

• Description :

  EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2) . EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently[1].

• CAS Number :

  [892415-28-0]

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319

• Target :

  EAAT

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/eaat2-activator-1.html

• Purity :

  98.91

• Solubility :

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  FC1=CC=CC(Cl)=C1CSC2=CC=C(C3=NC=CC=C3)N=N2

• Molecular Formula :

  C16H11ClFN3S

• Molecular Weight :

  331.80

• Precautions :

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations :

  [1]Xing X, et al. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett. 2011;21 (19) :5774-5777.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  EAAT2