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TERT activator-1

CAT: 0804-HY-402361-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-402361-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TERT activator-1 is a small molecule activator of telomerase reverse transcriptase (TERT) . TERT activator-1 promotes TERT transcription through the MEK/ERK/AP-1 signaling cascade. TERT activator-1 promotes adult neurogenesis and enhances neuromuscular function. TERT activator-1 reduces cellular senescence and systemic inflammation in aged mice, and can be used in the study of aging[1].
CAS Number
666699-46-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
AP-1; ERK; MEK
Type
Reference compound
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tert-activator-1.html
Purity
99.50
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=S(NC1=CC=C(C(Cl)=C1)F)(C2=CC(C)=C(F)C(C)=C2)=O
Molecular Formula
C14H12ClF2NO2S
Molecular Weight
331.77
Precautions
H302, H315, H319, H335
References & Citations
[1]Shim HS, et al. TERT activation targets DNA methylation and multiple aging hallmarks. Cell. 2024 Jul 25;187 (15) :4030-4042.e13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK1; ERK2; MEK1; MEK2

Chemical Information

N-(3-chloro-4-fluorophenyl)-4-fluoro-3,5-dimethylbenzenesulfonamide

N-(3-chloro-4-fluorophenyl)-4-fluoro-3,5-dimethylbenzenesulfonamide is an organic molecular entity.

CAS Number666699-46-3
PubChem CID2805068
IUPAC NameN-(3-chloro-4-fluorophenyl)-4-fluoro-3,5-dimethylbenzenesulfonamide
Molecular FormulaC14H12ClF2NO2S
Molecular Weight331.8
XLogP4
Topological Polar Surface Area54.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity444
SMILES
CC1=CC(=CC(=C1F)C)S(=O)(=O)NC2=CC(=C(C=C2)F)Cl
InChI
InChI=1S/C14H12ClF2NO2S/c1-8-5-11(6-9(2)14(8)17)21(19,20)18-10-3-4-13(16)12(15)7-10/h3-7,18H,1-2H3
InChIKey
JVUSVLUQMXGABO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(3-chloro-4-fluorophenyl)-4-fluoro-3,5-dimethylbenzenesulfonamide
CAS: 666699-46-3
CID: 2805068
Formula: C14H12ClF2NO2S
MW: 331.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight331.8
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass331.0245338
Monoisotopic Mass331.0245338
Topological Polar Surface Area54.6 Ų
Heavy Atom Count21
Formal Charge0
Complexity444
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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