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TrkB activator-1

CAT: 0804-HY-175483SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175483SSize:1 Each
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Description
TrkB activator-1 is a specific, orally active and brain-penetrant tropomyosin receptor kinase B (TrkB) activator. TrkB activator-1 shows potent antidepressant effects through activation of the activates the BDNF (brainderived neurotrophic factor) -Tropomyosin-related kinase B (TrkB) -CREB (cAMP response element binding protein) signaling aixs. TrkB activator-1 increaes neuroplasticity. TrkB activator-1 can be used for the research of neurological disease, such as depression[1].
CAS Number
3087336-56-6
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Trk Receptor
Related Pathways
Neuronal Signaling; Others; Protein Tyrosine Kinase/RTK
Field of Research
Neurological Disease
Smiles
O=C(N[C@H](C1=NC=CO1)C(C)C)[C@H]2CCN2C(C([2H])([2H])[2H])=O
Molecular Formula
C13H16D3N3O3
Molecular Weight
268.33
References & Citations
[1]Cheng X, et al. Discovery of Rapid-Acting, Orally Available Antidepressants by Activating TrkB Signaling. J Med Chem. 2025 Aug 14;68 (15) :16781-16801.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
TrkB

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