PF-4618433

CAT: 0804-HY-18312-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18312-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration[1][2].
CAS Number
[1166393-85-6]
UNSPSC
12352005
Target
Pyk2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pf-4618433.html
Purity
98.62
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(COC2=CC=CN=C2)=NN1)NC3=CC(C(C)(C)C)=NN3C4=CC=C(C)C=C4
Molecular Formula
C24H27N7O2
Molecular Weight
445.52
References & Citations
[1]Seungil H, et, al. Structural Characterization of Proline-Rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design. J Biol Chem. 2009 May 8; 284 (19) : 13193-201.|[2]Sumana P, et, al. A Pyk2 Inhibitor Incorporated Into a PEGDA-gelatin Hydrogel Promotes Osteoblast Activity and Mineral Deposition. Biomed Mater. 2019 Feb 27; 14 (2) : 025015.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-19550PF-06442609
HY-16387PF 00337210
HY-121775-01PF-00217830
HY-11045PF-03654746
HY-120811PF-04701475
HY-118339PF-4479745
HY-112598PF-06815345
HY-118952PF-06456384
HY-159648-01PF-07328948
HY-107591BPF-184

Alternative Products

CatalogName
MBS5756906PF-4618433
A13461-50PF-4618433 50mg
A13461-2PF-4618433 2mg
A13461-100PF-4618433 100mg
A13461-5PF-4618433 5mg
A13461-10PF-4618433 10mg
A13461-25PF-4618433 25mg
MBS579460PF-03084014 (PF-3084014)
MBS3606695-01PF-02413873
MBS3605744-01PF-562271

Popular Products