KI-7

• Description:

  KI-7 is an A2B adenosine receptor positive allosteric modulator. KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM) . KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively[1][2].

• UNSPSC:

  12352005

• Target:

  Adenosine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/ki-7.html

• Purity:

  99.16

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=CC=CC=C1)C(C2=CN(CC3=CC=CC=C3)C4=C2C=CC=C4)=O

• Molecular Formula:

  C23H18N2O2

• Molecular Weight:

  354.40

• References & Citations:

  [1]Trincavelli ML, et al. Allosteric modulators of human A2B adenosine receptor. Biochim Biophys Acta. 2014;1840 (3) :1194-1203.|[2]Trincavelli ML, et al. Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim Biophys Acta. 2014;1843 (12) :2957-2966.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1489263-00-4]