KI-TOX-A3

CAT: 0804-HY-176244-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-176244-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

KI-TOX-A3 is a selective protein-protein interaction (PPI) inhibitor targeting TOX protein (with an IC50 value of 0.51 μM for TOX-KAT7 interaction) . KI-TOX-A3 induces proteasomal degradation of TOX, restores KAT7-mediated H3K14 acetylation, reversing CD8+ T cell exhaustion and inhibiting T-cell acute lymphoblastic leukemia (T-ALL) cell proliferation. KI-TOX-A3 is promising for research of hematological tumors (e.g., T-ALL) [1].

CAS Number

1351116-34-1

UNSPSC

12352005

Target

Histone Acetyltransferase

Related Pathways

Epigenetics

Field of Research

Cancer

Purity

99.15

Solubility

DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OCC1=CC=C(C2=C(CC3=C4C=CC(O)=C3)C4=NC(N)=C2C#N)O1

Molecular Formula

C18H13N3O3

Molecular Weight

319.31

References & Citations

[1]Wu B, et al. Small molecule modulators of TOX protein re-invigorate T cell activity[J]. bioRxiv, 2025: 2025.03. 03.641115.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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