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KI-DX-014

CAT: 0804-HY-175238-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-175238-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KI-DX-014 is a DDX21 inhibitor with an IC50 of 3.31 μM. KI-DX-014 significantly inhibits the DDX21-RNA interaction and modulates ATPase activity and biomolecular condensate formation. KI-DX-014 reduces the DDX21-dependent release of P-TEFb from the 7SK snRNP complex, inhibits P-TEFb-dependent phosphorylation of the RNA polymerase II CTD, and induces developmental defects in zebrafish embryos. KI-DX-014 can be used for cancers and neurodegenerative disorders research[1].
CAS Number
[1309288-83-2]
UNSPSC
12352005
Target
ATP Synthase; DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel
Field of Research
Cancer; Neurological Disease
Purity
98.5600
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=C(C=C1)N2N=CC(CN3CCC(C(O)=O)(C3)N)=C2C
Molecular Formula
C17H22N4O3
Molecular Weight
330.38
References & Citations
[1]Aiba T, et al. Chemical Probe Discovery for DEAD-Box RNA-Binding Protein DDX21 Using Small-Molecule Microarrays. ACS Chem Biol. 2025 Jul 10.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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