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Ki 23057

CAT: 0804-HY-18187Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-18187Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ki 23057 is a competitive, orally active inhibitor for tyrosine kinase, which inhibits the phosphorylation of K-samII/FGF-R2, VEGF-R1, VEGF-R2, PDGF-Rβ and c-Kit, with IC50s of 88, 69, 83, 100 and 480 nM. Ki 23057 inhibits the proliferation of sclerogastric cancer cells OCUM-2MD3 and OCUM-8, and induces apoptosis. Ki 23057 exhibits antitumor efficacy in mouse models[1].
CAS Number
516523-31-2
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ki-23057.html
Smiles
COC1=C(OCCNCCO)C=C2N=CC=C(OC3=CC=C(NC4=CC=C(C(C)(C)C)C=C4)C=C3)C2=C1
Molecular Formula
C30H35N3O4
Molecular Weight
501.62
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Nakamura K, et al., A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for Scirrhous gastric cancer. Gastroenterology. 2006 Nov;131 (5) :1530-41.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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