Fumaric acid-d4

• Description:

  Fumaric acid-d4 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H335

• Target:

  Endogenous Metabolite

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Purity:

  98

• Solubility:

  10 mM in DMSO

• Smiles:

  [2H]OC (/C ([2H]) =C ([2H]) /C (O[2H]) =O) =O

• Molecular Formula:

  C4D4O4

• Molecular Weight:

  120.10

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132 (3) :301-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  194160-45-7