Fumaric acid-13C2

• Description:

  Fumaric acid-13C2 is the 13C-labeled Fumaric acid (HY-W015883) . Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension[1][2][3].

• UNSPSC:

  12352211

• Hazard Statement:

  H319

• Target:

  Endogenous Metabolite; Isotope-Labeled Compounds; NF-κB; p38 MAPK

• Related Pathways:

  MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

• Purity:

  99.9

• Smiles:

  O=[13C] (O) /C=C/[13C] (O) =O

• Molecular Formula:

  C2 13C2H4O4

• Molecular Weight:

  118.06

• Precautions:

  H319

• References & Citations:

  [1]Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132 (3) :301-8. |[2]Roh KB, et al. Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Food Chem Toxicol. 2013 Aug;58:423-31.|[3]Zhou Y, et al. Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. Exp Ther Med. 2021 Oct;22 (4) :1072.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  96503-56-9