Fumaric acid

• Description :

  Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension[1][2][3].

• UNSPSC :

  12352211

• Hazard Statement :

  H319

• Target :

  Endogenous Metabolite; NF-κB; p38 MAPK

• Type :

  Natural Products

• Related Pathways :

  MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/Fumaric_acid.html

• Purity :

  99.91

• Solubility :

  DMSO : 25 mg/mL (ultrasonic) |H2O : 11.11 mg/mL (ultrasonic)

• Smiles :

  O=C(O)/C=C/C(O)=O

• Molecular Formula :

  C4H4O4

• Molecular Weight :

  116.07

• Precautions :

  H319

• References & Citations :

  [1]Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132 (3) :301-8.|[2]Roh KB, et al. Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Food Chem Toxicol. 2013 Aug;58:423-31.|[3]Zhou Y, et al. Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. Exp Ther Med. 2021 Oct;22 (4) :1072.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  Human Endogenous Metabolite

• CAS Number :

  [110-17-8]