Fumaric acid (Standard)

CAT: 0804-HY-W015883R-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W015883R-01Size:50 mg
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Description
Fumaric acid (Standard) is the analytical standard of Fumaric acid. This product is intended for research and analytical applications. Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension[1][2][3].
CAS Number
[110-17-8]
UNSPSC
12352211
Hazard Statement
H319
Target
Endogenous Metabolite; NF-κB; p38 MAPK; Reference Standards
Type
Reference Standards
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fumaric-acid-standard.html
Purity
99.93
Smiles
O=C(O)/C=C/C(O)=O
Molecular Formula
C4H4O4
Molecular Weight
116.07
Precautions
P264-P280-P305+P351+P338
References & Citations
[1]Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132 (3) :301-8.|[2]Roh KB, et al. Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Food Chem Toxicol. 2013 Aug;58:423-31.|[3]Zhou Y, et al. Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. Exp Ther Med. 2021 Oct;22 (4) :1072.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

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