AX-53802

CAT: 0804-HY-172761Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172761Size:1 Each
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Description
AX-53802 is a ferroptosis inducer targeting GPX4 with an IC50 of 0.34 µM. AX-53802 forms a covalent bond with GPX4, initiating membrane translocation directly upon binding. AX-53802 and FAK/Src inhibitors promotes cell death. AX-53802 can be used for cancer study[1].
CAS Number
[1008482-71-0]
UNSPSC
12352211
Target
Ferroptosis; Glutathione Peroxidase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NC1CCCC1)C(C2=C(F)C=CC=C2)N(C(C#C)=O)C3=CC=C4C(OCO4)=C3
Molecular Formula
C23H21FN2O4
Molecular Weight
408.42
References & Citations
[1]Kunishige R, et al. Protein covariation networks for elucidating ferroptosis inducer mechanisms and potential synergistic drug targets. Commun Biol. 2025 Mar 31;8 (1) :480.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4

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