DSRM-3716

CAT: 0804-HY-W021879-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W021879-01Size:50 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection[1].
CAS Number
[58142-99-7]
Product Name Alternative
5-Iodoisoquinoline
UNSPSC
12352005
Hazard Statement
H302, H311, H315, H319, H402, H412
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dsrm-3716.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
IC1=CC=CC2=C1C=CN=C2
Molecular Formula
C9H6IN
Molecular Weight
255.06
Precautions
H302, H311, H315, H319, H402, H412
References & Citations
[1]Robert O Hughes, et al. Small Molecule SARM1 Inhibitors Recapitulate the SARM1 -/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate. Cell Rep. 2021 Jan 5;34 (1) :108588.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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