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DSR-71167

CAT: 0804-HY-120321Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120321Size:1 Each
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Description
DSR-71167 is an orally active mineralocorticoid receptor (MR) antagonist with an IC50 of 0.26 μM. DSR-71167 exhibits weak carbonic anhydrase (CA) inhibitory activity with an IC50 of 19 μM. DSR-71167 can dose-dependently increase urinary sodium excretion in rat models and has a very low risk of hyperkalemia in potassium-loading rat models. DSR-71167 lowers systolic blood pressure in hypertensive rat models. DSR-71167 can be used for research on hypertension and heart failure[1].
CAS Number
1355687-91-0
UNSPSC
12352005
Target
Carbonic Anhydrase; Mineralocorticoid Receptor
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=CC=C(C2=CC=CC=C2F)C(CNCC(F)F)=C1)NC3=CC=C(S(=O)(N)=O)C(OC)=C3.Cl
Molecular Formula
C23H23ClF3N3O4S
Molecular Weight
529.96
References & Citations
[1]Nariai T, et al. DSR-71167, a novel mineralocorticoid receptor antagonist with carbonic anhydrase inhibitory activity, separates urinary sodium excretion and serum potassium elevation in rats. J Pharmacol Exp Ther. 2015 Jul;354 (1) :2-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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