GNE-371

• UNSPSC Description:

  GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2).

• Target Antigen:

  DNA/RNA Synthesis

• Type:

  Dye Reagents

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/GNE-371.html

• Purity:

  98.21

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1C(NC=C2)=C2C(C3=C4N=CN(C)C4=CC(C(N5CCOCC5)=O)=C3)=CN1CCC=C

• Molecular Weight:

  431.49

• References & Citations:

  [1]Wang S, et al. GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like. J Med Chem. 2018 Oct 25;61(20):9301-9315.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  1926986-36-8