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GNE-371

CAT: 0804-HY-112803-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112803-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1 (2) .
CAS Number
1926986-36-8
UNSPSC
12171500
Target
DNA/RNA Synthesis
Type
Dye Reagents
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GNE-371.html
Purity
98.21
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(NC=C2)=C2C(C3=C4N=CN(C)C4=CC(C(N5CCOCC5)=O)=C3)=CN1CCC=C
Molecular Formula
C24H25N5O3
Molecular Weight
431.49
References & Citations
[1]Wang S, et al. GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like. J Med Chem. 2018 Oct 25;61 (20) :9301-9315.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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