PRN-371

• Description :

  PRN-371 is a potent and selective JAK3 inhibitor. PRN371 effectively suppresses natural killer/T-cell lymphoma cell proliferation and induces apoptosis through abrogation of the JAK3-STAT signaling. PRN-371 exhibits antitumor activity and can be used for the research of cancer, such as hematological malignancies[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; JAK

• Related Pathways :

  Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research :

  Cancer

• Smiles :

  O=C(C1=CNC2=NC=C(C3=CC=CC(NC(C=C)=O)=C3)N=C21)NC(C)(C)C

• Molecular Formula :

  C20H21N5O2

• Molecular Weight :

  363.41

• References & Citations :

  [1]Nairismägi M-, et al. Oncogenic activation of JAK3-STAT signaling confers clinical sensitivity to PRN371, a novel selective and potent JAK3 inhibitor, in natural killer/T-cell lymphoma. Leukemia. 2018 May;32 (5) :1147-1156.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  JAK3

• CAS Number :

  [1610974-55-4]