UNC3866 (TFA)

• UNSPSC Description:

  UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen (IC50=66±1.2 nM) and is more than 100-fold selective for CBX7 over the other nine members of this methyl-lysine (Kme) reader panel.

• Target Antigen:

  Histone Methyltransferase

• Type:

  Peptides

• Related Pathways:

  Epigenetics

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/unc3866-tfa.html

• Smiles:

  OC(C(F)(F)F)=O.O=C(C1=CC=C(C=C1)C(C)(C)C)N[C@H](C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN(CC)CC)C(N[C@@H](CO)C(OC)=O)=O)=O)=O)=O)CC2=CC=CC=C2

• Molecular Weight:

  909.04

• References & Citations:

  [1]Stuckey JI, et al. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat Chem Biol. 2016 Mar;12(3):180-7.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1872382-48-3