UNC3866

CAT: 0804-HY-100832-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100832-01Size:5 mg
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Description
UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen (IC50=66±1.2 nM) and is more than 100-fold selective for CBX7 over the other nine members of this methyl-lysine (Kme) reader panel.
CAS Number
[1872382-47-2]
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Histone Methyltransferase
Type
Peptides
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/UNC3866.html
Purity
99.50
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(C)C1=CC=C(C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN(CC)CC)C(N[C@H](C(OC)=O)CO)=O)=O)=O)=O)=O)C=C1
Molecular Formula
C43H66N6O8
Molecular Weight
795.02
Precautions
H302, H315, H319, H335
References & Citations
[1]Stuckey JI, et al. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat Chem Biol. 2016 Mar;12 (3) :180-7.
Shipping Conditions
Room Temperature
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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