Ac-LEVD-AFC

CAT: 0804-HY-P3115-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-P3115-02Size:5 mg

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Description

Ac-LEVD-AFC is capspase-4 fluorogenic substrate peptide that can be used for caspase-4 activity studies[1].

CAS Number

1092077-23-0

UNSPSC

12352209

Target

Biochemical Assay Reagents; Fluorescent Dye

Type

Peptides

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ac-levd-afc.html

Purity

98.11

Solubility

10 mM in DMSO

Smiles

FC(F)(C(C1=CC=C(NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(C)C)=O)=O)=O)=O)C=C1O2)=CC2=O)F

Molecular Formula

C32H40F3N5O11

Molecular Weight

727.68

References & Citations

[1]Pallett MA, et al. Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells. Mucosal Immunol. 2017 May;10 (3) :602-612.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Chemical Information

Ac-Leu-Glu-Val-Asp-AFC

CAS Number	1092077-23-0
PubChem CID	25108577
IUPAC Name	(4S)-4-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-5-[[(2S)-1-[[(2S)-3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
Molecular Formula	C32H40F3N5O11
Molecular Weight	727.7
XLogP	1.4
Topological Polar Surface Area	246
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	17
Heavy Atom Count	51
Formal Charge	0
Complexity	1380

SMILES

CC(C)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)C

InChI

InChI=1S/C32H40F3N5O11/c1-14(2)10-21(36-16(5)41)30(49)38-20(8-9-24(42)43)28(47)40-27(15(3)4)31(50)39-22(13-25(44)45)29(48)37-17-6-7-18-19(32(33,34)35)12-26(46)51-23(18)11-17/h6-7,11-12,14-15,20-22,27H,8-10,13H2,1-5H3,(H,36,41)(H,37,48)(H,38,49)(H,39,50)(H,40,47)(H,42,43)(H,44,45)/t20-,21-,22-,27-/m0/s1

InChIKey

FETZKXHXYOHAAN-LFYAFONDSA-N

Chemical Structure

2D Structure

CAS: 1092077-23-0

CID: 25108577

Formula: C32H40F3N5O11

MW: 727.7

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	727.7
XLogP3	1.4
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	17
Exact Mass	727.26764160
Monoisotopic Mass	727.26764160
Topological Polar Surface Area	246 Å²
Heavy Atom Count	51
Formal Charge	0
Complexity	1380
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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HY-P1005-01	Ac-DEVD-AFC
HY-P2617	Ac-WEHD-AFC
HY-P5955	Ac-AAVALLPAVLLALLAP-LEVD-CHO
HY-P5983-01	Ac-VEID-AFC
HY-P1093-01	Ac-LEHD-AFC
HY-P2377-01	Ac-YVAD-AFC

Alternative Products

Catalog	Name
A8759-25	Ac-LEVD-AFC
1109-1000	Caspase-4 Substrate LEVD-AFC
T85585-01	Ac-LEVD-CHO
CCP3056-01	Ac-LEVD-pNA
ALX-260-083-M005	Ac-LEVD-AMC
MBS5822196	Ac-AAVALLPAVLLALLAP-LEVD-CHO
TP3733-01	Ac-LEVD-CHO TFA
254517	Ac-IEPD-AFC
T36343-01	Ac-LETD-AFC
MBS3613560-01	Ac-DEVD-AFC

Ac-LEVD-AFC

Chemical Information

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