17-HETE

• Description :

  17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy[1][2].

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Cytochrome P450; Na+/K+ ATPase

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/17-hete.html

• Concentration :

  312.04 μM * 500 μL in Ethanol

• Purity :

  98.2

• Solubility :

  10 mM in DMSO

• Smiles :

  CCCC(C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O)O

• Molecular Formula :

  C20H32O3

• Molecular Weight :

  320.47

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Isse FA, et al., 17- (R/S) -hydroxyeicosatetraenoic acid (HETE) induces cardiac hypertrophy through the CYP1B1 in enantioselective manners. Prostaglandins Other Lipid Mediat. 2023 Oct;168:106749.|[2]Carroll MA, e al., Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996 Oct;271 (4 Pt 2) :R863-9.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Solution, -20°C, 2 years

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CYP1

• CAS Number :

  [128914-47-6]