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COTC

CAT: 0804-HY-N12255Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N12255Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COTC is a bacterial metabolite with anticancer activity that is found in S. griseosporeus. COTC inhibits glyoxalase in the presence of glutathione (GSH) . COTC also inhibits the proliferation of HeLa cells (IC50 = 18 µg/mL), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model[1].
CAS Number
[57449-30-6]
UNSPSC
12352211
Target
Glyoxalase (GLO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cotc.html
Smiles
C/C=C/C(OCC1=C[C@@H](O)[C@@H](O)[C@@H](O)C1=O)=O
Molecular Formula
C11H14O6
Molecular Weight
242.23
References & Citations
[1]Takeuchi T, et al. A glyoxalase I inhibitor of a new structural type produced by Streptomyces. J Antibiot (Tokyo) . 1975 Oct;28 (10) :737-42.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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