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EPPI rabbit pAb

CAT: 0855-ES16707-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES16707-02Size:100 µL
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Background
This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Description
This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014],
UniProt
O95925
Swiss Prot
O95925
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human EPPI AA range: 55-105
Target
EPPI
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
[Isoform 1]: Secreted. Cell surface. Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.
Gene ID (Human)
100526773

UniProtKB · O95925

Eppin

EPPI_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95925
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EPPIN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A6PVD6, Q86TP9, Q96SD7, Q9HD30
Protein keywords

Coding sequence diversity

Alternative splicing

Molecular function

AntimicrobialProtease inhibitorSerine protease inhibitor

PTM

Disulfide bond

Technical term

Proteomics identificationReference proteome

Cellular component

Secreted

Domain

Signal

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