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NLRP3-IN-83

CAT: 0804-HY-175814Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175814Size:1 Each
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Description
NLRP3-IN-83 is a selective and orally active NLRP3 inflammasome activation inhibitor. NLRP3-IN-83 exhibits good inhibitory IL-1β activity with an IC50 of 1.4 μM by blocking NLRP3, independent of NF-κB signaling. NLRP3-IN-83 only slightly inhibits AIM2 inflammasome pathway, but has no effect on NLRC4 inflammasome. NLRP3-IN-83 prevent cell pyroptosis and exhibits significant anti-inflammatory efficacy in ulcerative colitis model. NLRP3-IN-83 can be used for the study of inflammatory bowel disease (IBD) [1].
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR) ; Pyroptosis
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
OC1=C2C(C=CC(CNC3=CC=C(OC)C=C3)=N2)=CC=C1
Molecular Formula
C17H16N2O2
Molecular Weight
280.32
References & Citations
[1]Zhang X, et al. Discovery of novel 8-hydroxyquinoline derivatives as NLRP3 inflammasome inhibitors with therapeutic potential for inflammatory bowel disease. Eur J Med Chem. 2025 Nov 15;298:118023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; NLRP3

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