Mepazine (hydrochloride)

• Product Name Alternative:

  Pecazine (hydrochloride)

• UNSPSC Description:

  Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis[1].

• Target Antigen:

  Apoptosis; MALT1

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease;NF-κB

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mepazine-hydrochloride.html

• Purity:

  99.94

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)|H2O : 2.22 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  CN1CC(CN2C3=C(C=CC=C3)SC4=CC=CC=C24)CCC1.[H]Cl

• Molecular Weight:

  346.92

• References & Citations:

  [1]Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22(6):825-37.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  2975-36-2