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Mepazine (hydrochloride)

CAT: 0804-HY-121282A-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-121282A-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis[1].
CAS Number
2975-36-2
Product Name Alternative
Pecazine (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; MALT1
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mepazine-hydrochloride.html
Purity
99.25
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 2.22 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN1CC(CN2C3=C(C=CC=C3)SC4=CC=CC=C24)CCC1.[H]Cl
Molecular Formula
C19H23ClN2S
Molecular Weight
346.92
Precautions
H302
References & Citations
[1]Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22 (6) :825-37.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

10H-Phenothiazine, 10-((1-methyl-3-piperidinyl)methyl)-, hydrochloride (1:1)
CAS Number2975-36-2
PubChem CID102907
IUPAC Name10-[(1-methylpiperidin-3-yl)methyl]phenothiazine;hydrochloride
Molecular FormulaC19H23ClN2S
Molecular Weight346.9
Topological Polar Surface Area31.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity352
SMILES
CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42.Cl
InChI
InChI=1S/C19H22N2S.ClH/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21;/h2-5,8-11,15H,6-7,12-14H2,1H3;1H
InChIKey
RLCFKYRNUBRPIK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 10H-Phenothiazine, 10-((1-methyl-3-piperidinyl)methyl)-, hydrochloride (1:1)
CAS: 2975-36-2
CID: 102907
Formula: C19H23ClN2S
MW: 346.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight346.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass346.1270476
Monoisotopic Mass346.1270476
Topological Polar Surface Area31.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity352
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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