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Mepazine (acetate)

CAT: 0804-HY-121282BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-121282BSize:1 Each
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Description
Mepazine acetate (Pecazine acetate) is a drug that has the activity to inhibit the protease activity of MALT1. Mepazine acetate is often used to study the role of MALT1 in biology. Treatment of mouse bone marrow precursor cells with mepazine acetate strongly inhibited RANK ligand (RANKL) -induced osteoclast formation. Mepazine acetate also inhibited the expression of multiple osteoclast markers such as TRAP, feline hepsin K, and calcitonin. The protective effect of mepazine acetate was not affected by MALT1 deficiency. The mechanism of action of mepazine acetate may involve MALT1-independent mechanisms, and this aspect needs to be considered in future studies[1].
CAS Number
24360-97-2
Product Name Alternative
Pecazine (acetate)
UNSPSC
12352005
Target
Apoptosis; MALT1
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/mepazine-acetate.html
Smiles
O=C(C)O.CN(CCC1)CC1CN2C3=C(C=CC=C3)SC4=C2C=CC=C4
Molecular Formula
C21H26N2O2S
Molecular Weight
370.51
References & Citations
[1]Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22 (6) :825-37.|[2]Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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